Microchannel network hydrogel induced ischemic blood perfusion connection
- Authors
- Lee, Jung Bok; Kim, Dae-Hyun; Yoon, Jeong-Kee; Park, Dan Bi; Kim, Hye-Seon; Shin, Young Min; Baek, Wooyeol; Kang, Mi-Lan; Kim, Hyun Jung; Sung, Hak-Joon
- Issue Date
- Jan-2020
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- VASCULAR-RESISTANCE; GELATIN HYDROGELS; MOUSE MODEL; ANGIOGENESIS; INFLAMMATION; GROWTH; PATHOPHYSIOLOGY; POLARIZATION; STRATEGIES; INDUCTION
- Citation
- NATURE COMMUNICATIONS, v.11, no.1, pp 1 - 14
- Pages
- 14
- Journal Title
- NATURE COMMUNICATIONS
- Volume
- 11
- Number
- 1
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146200
- DOI
- 10.1038/s41467-020-14480-0
- ISSN
- 2041-1723
- Abstract
- Angiogenesis induction into damaged sites has long been an unresolved issue. Local treatment with pro-angiogenic molecules has been the most common approach. However, this approach has critical side effects including inflammatory coupling, tumorous vascular activation, and off-target circulation. Here, the concept that a structure can guide desirable biological function is applied to physically engineer three-dimensional channel networks in implant sites, without any therapeutic treatment. Microchannel networks are generated in a gelatin hydrogel to overcome the diffusion limit of nutrients and oxygen three-dimensionally. Hydrogel implantation in mouse and porcine models of hindlimb ischemia rescues severely damaged tissues by the ingrowth of neighboring host vessels with microchannel perfusion. This effect is guided by microchannel size-specific regenerative macrophage polarization with the consequent functional recovery of endothelial cells. Multiple-site implantation reveals hypoxia and neighboring vessels as major causative factors of the beneficial function. This technique may contribute to the development of therapeutics for hypoxia/inflammatory-related diseases. Restoration of blood flow to damaged sites has commonly involved treatment with pro-angiogenic molecules but these have undesired side effects. H
- Files in This Item
-
Go to Link
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.