Synthesis and biological activity of 5-{4-[2-(Methyl-p-substituted phenylamino)ethoxy]benzyl}thiazolidine-2,4-diones
- Authors
- Gim, Hyo Jin; Kang, BoMi; Jeon, Raok
- Issue Date
- Sep-2007
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- thiazolidinedione; PPAR gamma; nitric oxide; diabetes; inflammation
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.30, no.9, pp 1055 - 1061
- Pages
- 7
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 30
- Number
- 9
- Start Page
- 1055
- End Page
- 1061
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14640
- DOI
- 10.1007/BF02980237
- ISSN
- 0253-6269
1976-3786
- Abstract
- Thiazolidinedione derivatives are potential antidiabetic drugs that bind and activate peroxisome proliferator activated receptor gamma (PPAR gamma), which is a member of the nuclear hormone receptor superfamily and enhances insulin sensitivity. In an effort to develop a novel and effective thiazolidinclione derivative, 5-{4-[2-(methyl-p-substituted phenylamino)ethoxy]benzyl)thiazolidine-2,4-diones 7 have been prepared by Mitsunobu reaction of the hydrophobic segment, methyl-p-substituted phenylaminoethanol 4 with hydroxybenzylthiazolidinedione 5 and their ability to activate PPARy and inhibit LIPS-induced NO production were evaluated.
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