Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos
- Authors
- Kumar, Vijay; Goutam, Ravi Shankar; Park, Soochul; Lee, Unjoo; Kim, Jaebong
- Issue Date
- Aug-2021
- Publisher
- MDPI
- Keywords
- FGF; FGFR; embryonic development; germ layer formation; transcription regulation; embryonic patterning
- Citation
- CELLS, v.10, no.8, pp 1 - 21
- Pages
- 21
- Journal Title
- CELLS
- Volume
- 10
- Number
- 8
- Start Page
- 1
- End Page
- 21
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146489
- DOI
- 10.3390/cells10082148
- ISSN
- 2073-4409
2073-4409
- Abstract
- Fibroblast growth factors (FGFs) comprise a large family of growth factors, regulating diverse biological processes including cell proliferation, migration, and differentiation. Each FGF binds to a set of FGF receptors to initiate certain intracellular signaling molecules. Accumulated evidence suggests that in early development and adult state of vertebrates, FGFs also play exclusive and context dependent roles. Although FGFs have been the focus of research for therapeutic approaches in cancer, cardiovascular disease, and metabolic syndrome, in this review, we mainly focused on their role in germ layer specification and axis patterning during early vertebrate embryogenesis. We discussed the functional roles of FGFs and their interacting partners as part of the gene regulatory network for germ layer specification, dorsal-ventral (DV), and anterior-posterior (AP) patterning. Finally, we briefly reviewed the regulatory molecules and pharmacological agents discovered that may allow modulation of FGF signaling in research.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.