An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice
- Authors
- Li, Shangyong; Jin, Mengfei; Wu, Yanhong; Jung, Samil; Li, Dandan; He, Ningning; Lee, Myeong-sok
- Issue Date
- 1-Jan-2021
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Colon-targeted drug delivery; enzyme-triggered controlled release; ulcerative colitis; intestinal homeostasis; gut microbiota
- Citation
- DRUG DELIVERY, v.28, no.1, pp 1120 - 1131
- Pages
- 12
- Journal Title
- DRUG DELIVERY
- Volume
- 28
- Number
- 1
- Start Page
- 1120
- End Page
- 1131
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146835
- DOI
- 10.1080/10717544.2021.1934189
- ISSN
- 1071-7544
1521-0464
- Abstract
- Oral route colon-targeted drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC). However, CDDSs are challenging owing to the physiological and anatomical barriers associated with the gastrointestinal tract (GIT). In this study, we developed an effective enzyme-triggered controlled release system using curcumin-cyclodextrin (CD-Cur) inclusion complex as core and low molecular weight chitosan and unsaturated alginate resulting nanoparticles (CANPs) as shell. The formed CD-Cur-CANPs showed a narrow particle-size distribution and a compact structure. In vitro drug release determination indicated that CD-Cur-CANPs showed pH-sensitive and alpha-amylase-responsive release characteristics. Furthermore, in vivo experiments demonstrated that oral administration of CD-Cur-CANPs had an efficient therapeutic efficacy, strong colonic biodistribution and accumulation, rapid macrophage uptake, promoted colonic epithelial barrier integrity and modulated production of inflammatory cytokines, reshaped the gut microbiota in mice with dextran sodium sulfate (DSS)-induced colitis. Taken together, our synthetic CD-Cur-CANPs are a promising synergistic colon-targeted approach for UC treatment.
- Files in This Item
-
Go to Link
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146835)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.