Cytotoxic Ceanothane- and Lupane-Type Triterpenoids from the Roots of Ziziphus jujuba
- Authors
- Kang, KB (Kang, Kyo Bin); Kim, JW (Kim, Jung Wha); Oh, WK (Oh, Won Keun); Kim, J (Kim, Jinwoong); Sung, SH (Sung, Sang Hyun)
- Issue Date
- Sep-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.79, no.9, pp 2364 - 2375
- Pages
- 12
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 79
- Number
- 9
- Start Page
- 2364
- End Page
- 2375
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147034
- DOI
- 10.1021/acs.jnatprod.6b00525
- ISSN
- 0163-3864
1520-6025
- Abstract
- Ziziphus jujuba, a plant in the family Rhamnaceae, is used in several Asian countries as a food and traditional medicine. Fifteen new ceanothane-type (1-15) and three new lupane-type triterpenoids (16-18) were isolated from the roots of Z. jujuba, as well, as 12 previously known triterpenoids (19-30). Their structures were elucidated by 1D and 2D NMR spectroscopic and HR mass spectrometric data analysis. Compounds 12 and 13 were found to possess a rare E-ring gamma-lactone structure, and 14 was assigned as the first 2,28-dinorlupane derivative isolated as a natural product. Twenty-five of the isolates were examined for cytotoxicity against human hepatocellular carcinoma HepG2 cells, and compounds 6-8, 14, 17, 23, 25, 29, and 30 showed cytotoxicity with IC50 values ranging from 1.9 to 5.9 mu M.
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