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Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa
- Authors
- Kim, HW (Kim, Hyun Woo); Park, J (Park, Junha); Kang, KB (Kang, Kyo Bin); Kim, TB (Kim, Tae Bum); Oh, WK (Oh, Won Keun); Kim, J (Kim, Jinwoong); Sung, SH (Sung, Sang Hyun)
- Issue Date
- Sep-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.79, no.9, pp 2376 - 2383
- Pages
- 8
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 79
- Number
- 9
- Start Page
- 2376
- End Page
- 2383
- ISSN
- 0163-3864
1520-6025
- Abstract
- Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.
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