Development of poly(ε-Caprolactone) scaffold loaded with simvastatin and beta-cyclodextrin modified hydroxyapatite inclusion complex for bone tissue engineering
- Authors
- Lee, Jung Bok; Kim, Ji Eun; Bae, Min Soo; Park, Su A; Balikov, Daniel A.; Sung, Hak-joon; Jeon, Hoon Bong; Park, Hun Kuk; Um, Soong Ho; Lee, Kook Sun; Kwon, Il Keun
- Issue Date
- Feb-2016
- Publisher
- MDPI Open Access Publishing
- Citation
- Polymers, v.8, no.2, pp 1 - 10
- Pages
- 10
- Journal Title
- Polymers
- Volume
- 8
- Number
- 2
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147077
- DOI
- 10.3390/polym8020049
- ISSN
- 2073-4360
2073-4360
- Abstract
- In this study, we developed poly(ε-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. β-cyclodextrin (βCD) was grafted to hydroxyapatite (HAp) and this βCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the βCD and adamantane (AD) or between βCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the β-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs.
- Files in This Item
-
Go to Link
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.