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ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response
- Authors
- Lee S.H.; Boire T.C.; Lee J.B.; Gupta M.K.; Zachman A.L.; Rath R.; Sung H.-J.
- Issue Date
- Nov-2014
- Publisher
- Royal Society of Chemistry
- Citation
- Journal of Materials Chemistry B, v.2, no.41, pp 7109 - 7113
- Pages
- 5
- Journal Title
- Journal of Materials Chemistry B
- Volume
- 2
- Number
- 41
- Start Page
- 7109
- End Page
- 7113
- ISSN
- 2050-7518
2050-750X
- Abstract
- A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineering applications. © 2014 the Partner Organisations.
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