PEG grafted AM SURE (TM) resin and its application to solid-phase peptide synthesis
- Authors
- Kim, M (Kim, Mira); Park, YS (Park, Yong-Sun); Shin, DS (Shin, Dong-Sik); Lee, S (Lee, Song); Lee, YS (Lee, Yoon-Sik)
- Issue Date
- Aug-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Core-shell type resin bead; Polymer support; Solid-phase peptide synthesis
- Citation
- TETRAHEDRON LETTERS, v.53, no.34, pp 4576 - 4579
- Pages
- 4
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 53
- Number
- 34
- Start Page
- 4576
- End Page
- 4579
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147592
- DOI
- 10.1016/j.tetlet.2012.06.074
- ISSN
- 0040-4039
- Abstract
- PEGylated core-shell type resin (PEG-AM SURE) was developed by modifying the surface of AM SURE (TM) resin with diamino PEG. The conditions for the PEG coupling reaction were optimized by adjusting PEG chain cross-linking and the amount of free amino groups to ensure a enough loading level of functional groups on the resin (>0.30-0.39 mmol NH2/g). The resulting PEG-AM SURE resin showed better performance than conventional resins during solid-phase peptide synthesis of JR10-mer and beta 2m(58-69) 12-mer. (C) 2012 Elsevier Ltd. All rights reserved.
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