Evaluation of GENESIS-BCPTM Scaffold Composed of Hydroxyapatite and β-Tricalcium Phosphate on Bone Formation
- Authors
- Yang, Dae Hyeok; Park, Ha Na; Bae, Min Soo; Lee, Jung Bok; Heo, Dong Nyoung; Lee, Won Jun; Park, Young Min; Cho, Young Hwan; Kim, Duck-Su; Kwon, Il Keun
- Issue Date
- Jun-2012
- Publisher
- 한국고분자학회
- Keywords
- hydroxyapatite (HAp); beta-tricalcium phosphate (β-TCP); GENESIS-BCPTM; mouse skull test; hematoxylin and eosin stain.
- Citation
- Macromolecular Research, v.20, no.6, pp 627 - 633
- Pages
- 7
- Journal Title
- Macromolecular Research
- Volume
- 20
- Number
- 6
- Start Page
- 627
- End Page
- 633
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147607
- DOI
- 10.1007/s13233-012-0090-6
- ISSN
- 1598-5032
2092-7673
- Abstract
- The purpose of this study was to evaluate the effects of a GENESIS-BCPTM scaffold composed of
hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) on bone formation. The rela tive ratio of components
forming GENESIS-BCPTM was investigated by confirming the molar ratio of Ca/P through energy dispersive spectrometer
(EDS) analysis. The results being that the scaffold is comprised of 60% HAp and 40% β-TCP. Moreover,
scanning electron microscopy (SEM) images showed a unique surface morphology similar to a soccer ball. X-ray
diffraction (XRD) analysis showed that the porosity, crystallinity, and Ca/P ratio were 65.5%, 84.9%, and 1.61%,
respectively. In vitro tests including cytotoxicity and cell proliferation showed a good biocompatibility of GENESIS-
BCPTM. In vivo tests, including mouse skull test, and hematoxylin and eosin stains of GENESIS-BCPTM
implanted in rabbit and human subjects showed that the bone graft is effective to accelerate new bone formation. It
was concluded that GENESIS-BCPTM can be used as an effective alloplast bone graft.
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