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잔류용매 제거를 통한 신경전극의 생체적합성 향상Assessment of the Biocompatibility of Neural Electrode by Solvent Extraction

Other Titles
Assessment of the Biocompatibility of Neural Electrode by Solvent Extraction
Authors
허동녕이정복남윤식윤인찬서준교권일근
Issue Date
Mar-2011
Publisher
한국생체재료학회
Citation
생체재료학회지, v.15, no.1, pp 17 - 21
Pages
5
Journal Title
생체재료학회지
Volume
15
Number
1
Start Page
17
End Page
21
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147788
ISSN
1226-4601
2055-7124
Abstract
To enhance biocompatibility of neural electrode, residual solvent in the neural electrode was reduced by solvent extraction and ultra-sonication processes. The solvent-extracted polyimide (PI) films are subcutaneously implanted in the mouse. The biocompatibility of the PI film was analyzed using the cytotoxicity, RT-PCR, and H & E staining. The solvent-extracted PI film shows better short term biocompatible characteristics over control and non-treated PI film. This solvent reduction method can be used to increase the biocompatibility of neural electrode.
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