키토산 나노 섬유 지지체의 제작과 생체공학적 응용

Abstract

Functional biomaterial research has been directed toward the development of improved scaffolds for tissue engineering. Many biodegradable and biocompatible polymers both synthetic polymers and natural polymers have been used to make scaffolds. Among the naturally derived polymers, chitosan which is deacetylated derivative of chitin, is widely used for biomedical applications such as tissue engineering scaffolds, drug delivery, and wound dressing due to their unique biological properties such as biocompatibility, biodegradability, anti-bacterial, and non-toxicity. In the recent years, electrospinning has been used to be a novel technique to fabricate nano/micro fibers. These nano/micro fibers have been applied in biomedical fields as tissue engineering scaffold because of their high surface area and porosity. In this reason, there has been a growing interest in electrospinning using chitosan in order to improve similarities to natural tissue. This article reviews the recent and relevant reports of the chitosan nanofibers fabricated by electrospinning and their biomedical applications.