Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate
- Authors
- Kang, Wonku; Kim, Kibum; Kim, Eun-Young; Kwon, Kwang-il; Bang, Jun Seok; Yoon, Young-Ran
- Issue Date
- Jul-2008
- Publisher
- SPRINGER
- Citation
- EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v.64, no.10, pp 1027 - 1030
- Pages
- 4
- Journal Title
- EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Volume
- 64
- Number
- 10
- Start Page
- 1027
- End Page
- 1030
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148158
- DOI
- 10.1007/s00228-008-0524-4
- ISSN
- 0031-6970
1432-1041
- Abstract
- Purpose Talniflumate was designed as a prodrug of niflumic acid, a potent analgesic and anti-inflammatory drug, which is widely prescribed for treating rheumatoid diseases. The prandial effect on talniflumate absorption remains unclear; therefore, this study investigated the effect of food on the systemic exposure to niflumic acid in healthy volunteers.Methods Volunteers received a single 740-mg dose of talniflumate 30 min after consuming a high-fat breakfast, a low-fat breakfast, or no food ( fasting condition). Plasma concentrations of both talniflumate and niflumic acid were measured using validated high-performance liquid chromatography coupled to tandem mass spectrometry.
Results The maximum concentration of niflumic acid was 224 +/- 193 ng/ml at similar to 2.7 h in the fasted condition compared with 886 +/- 417 ng/ml (p< 0.05) at 1.8 h and 1,159 +/- 508 ng/ml (p< 0.01) at 2.2 h with the low- and high-fat meals, respectively. The mean area under the curve from zero to infinity (AUC(inf)) values after the low- and high-fat meals were four- and fivefold, respectively, the value while fasting ( p< 0.05).
Conclusions It is strongly recommended that talniflumate be taken after a meal to increase systemic exposure to its active metabolite. Our results suggest a reduction in the daily dosage of talniflu
- Files in This Item
-
Go to Link
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148158)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.