부프로피온과 바레니클린을 사용한 금연치료요법의 경제성 평가 연구를 위한 주요 문헌검색 엔진 비교

Abstract

Background: The systematic retrieval processing is essential to search articles, especially, in pharmacoeconomics area. However, there has been limited information and knowledge about features and differences among medical search engines. Objectives: This study was aimed to compare four major retrieval engines (PubMed, Ovid MEDLINE, and EMBASE) frequently used for drug literature search to collect clinical data for pharmacoeconomic evaluation. Methods: Four major retrieval engines were compared in terms of search results. The pharmacoeconomic evaluation senario was made that pharmacoeconomic evaluation of two oral medicines for smoking cessation, bupropione and varenicline. Free text keyword search was conducted with bupropione, varenicline, and smoking cessation. Search limits included period, types of study designs (randomized controlled trials and systemic reviews), language. SAS 9.1 and Excel 2002 were used for statistical analysis. Results and Conclusions: EMBASE provided the largest number of articles in each search step among four engines. EMBASE also had many unique articles that were retrievable exclusively from its engine and Medline and EMBASE retrieved many common articles in most of search process. Articles from US were more than 50% in EMBASE and Medline. EMBASE has greater number of articles originated from Europe.