Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-κB signaling pathway
- Authors
- Yong Jin Song; Dae Young Lee; Su-Nam Kim; Kang Ro Lee; Hyang Woo Lee; Jeung-Whan Han; Dong-Won Kang; Hoi Young Lee; 김용기
- Issue Date
- Dec-2005
- Publisher
- Pharmaceutical Press
- Citation
- Journal of Pharmacy and Pharmacology, v.57, no.12, pp 1591 - 1597
- Pages
- 7
- Journal Title
- Journal of Pharmacy and Pharmacology
- Volume
- 57
- Number
- 12
- Start Page
- 1591
- End Page
- 1597
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148709
- DOI
- 10.1211/jpp.57.12.0009
- ISSN
- 0022-3573
2042-7158
- Abstract
- Treatment with ergolide, a sesquiterpene lactone from Inula britannica var chinensis, caused the induction of apoptosis in Jurkat T cells, which was confirmed by DNA fragmentation, caspase-3 activation and cleavage of poly(ADP-ribose) polymerase in response to ergolide. Furthermore, mitochondrial dysfunction appeared to be associated with ergolide-induced apoptosis, because Bax translocation and cytochrome c release were stimulated by ergolide. In parallel, the nuclear factor-κB (NF-κB) signaling pathway was significantly inhibited by ergolide, which was accompanied by down-regulation of cell survival molecules, such as X-chromosome-linked inhibitor of apoptosis and Bcl-2. In addition, the JNK signaling pathway was involved in ergolide-induced apoptosis. Collectively, our results identified a new mechanism for the anti-cancer property of ergolide, attributable to the induction of apoptosis through down-regulation of cell survival signal molecules resulting from inhibition of the NF-κB signaling pathway.
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