Biological Monitoring of Bisphenol A in a Korean Population
DC Field | Value | Language |
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dc.contributor.author | Mihi Yang | - |
dc.contributor.author | Soo-Young Kim | - |
dc.contributor.author | Su-Man Lee | - |
dc.contributor.author | Seong-Sil Chang | - |
dc.contributor.author | Toshihiro Kawamoto | - |
dc.contributor.author | Jae-Yeon Jang | - |
dc.contributor.author | Yoon-Ok Ahn | - |
dc.date.accessioned | 2022-04-19T12:04:46Z | - |
dc.date.available | 2022-04-19T12:04:46Z | - |
dc.date.issued | 2003-05 | - |
dc.identifier.issn | 0090-4341 | - |
dc.identifier.issn | 1432-0703 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149166 | - |
dc.description.abstract | To conduct proper biological monitoring of environmental exposure to bisphenol A (BPA), the variation in host susceptibility need to be investigated. For this purpose, we studied effects of genetic polymorphism in sulfotransferase (SULT) 1A1 on urinary BPA, a biomarker for BPA exposure, in 73 Koreans (male, 34; female, 39; age, 48.9 ± 11.9 yrs). We used reverse phase-HPLC/FD for analysis of urinary BPA and obtained information from each subject on lifestyle, environment, and potential exposure to BPA via food. The HPLC/FD method showed good reproducibility (CVs < 0.1) and a relatively sensitive detection limit of 0.012 μg/L. These methods yielded a geometric mean of urinary BPA as 9.54 μg/L (8.91 μg/g creatinine), with a geometric standard deviation of 8.32 μg/L. Among potential routes for BPA exposure, only “vinyl wrapping of microwave heating” indicated a borderline positive association with urinary BPA level (p = 0.1). After PCR-RFLP, we found the allele frequencies of SULT1A1*1 and SULT1A1*2 were 0.89 and 0.11, respectively within the subjects. As the SULT1A1*1 allele of SULT1A1 is known to be a rapid sulfonylation-allele, the presence of SULT1A1*1 is suspected to rapidly dispose of environmental BPA. However resultant, urinary BPA levels were not significantly different between the SULT1A1*1/*1 identified subjects and the SULT1A1*1/*2 subjects. Therefore, to clarify host variability in urinary BPA level, different genetic polymorphisms in BPA metabolic enzymes other than SULT1A1 should be further studied. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer-Verlag | - |
dc.title | Biological Monitoring of Bisphenol A in a Korean Population | - |
dc.title.alternative | 한국인에서 비스페놀A 생물학적 모니터링 | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s00244-002-2124-0 | - |
dc.identifier.scopusid | 2-s2.0-0242584521 | - |
dc.identifier.wosid | 000182102400015 | - |
dc.identifier.bibliographicCitation | Archives of Environmental Contamination and Toxicology, v.44, no.4, pp 546 - 551 | - |
dc.citation.title | Archives of Environmental Contamination and Toxicology | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 546 | - |
dc.citation.endPage | 551 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00244-002-2124-0 | - |
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