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Yakuchinone과 그 유도체의 합성 및 Nitric Oxide 생성 저해효능Synthesis of Yakuchinone Derivatives and Their Inhibitory Activities on Nitric Oxide Synthesis

Other Titles
Synthesis of Yakuchinone Derivatives and Their Inhibitory Activities on Nitric Oxide Synthesis
Authors
윤정화안한나류재하김희두
Issue Date
Feb-2001
Publisher
대한약학회
Citation
약 학 회 지, v.45, no.1, pp 16 - 22
Pages
7
Journal Title
약 학 회 지
Volume
45
Number
1
Start Page
16
End Page
22
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149646
ISSN
0377-9556
2383-9457
Abstract
Novel yakuchinone derivatives have designed, synthesized and evaluated their inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages. From this study, some enone compounds have been found to be highly active in the assay. In view of the importance of NO in septic shock and inflammation, these compounds may be useful candidates for the development of new drug to treat endotoxemia and inflammation accmpanying overproduction of NO.
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약학대학 (약학부)
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