Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages
- Authors
- Jeon, SD; Lim, JS; Moon, CK
- Issue Date
- Feb-2001
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Carbofuran; Cell-mediated immune responses; Cytokines; Delayed type hypersensitivity; Macrophages; Mixed lymphocyte reaction; Nitric oxide; Splenocytes
- Citation
- TOXICOLOGY LETTERS, v.119, no.2, pp 143 - 155
- Pages
- 13
- Journal Title
- TOXICOLOGY LETTERS
- Volume
- 119
- Number
- 2
- Start Page
- 143
- End Page
- 155
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149687
- DOI
- 10.1016/S0378-4274(00)00307-6
- ISSN
- 0378-4274
1879-3169
- Abstract
- The effects of carbofuran (2,3-dihydro-2,2-dimethyl-7-benzo-furanol N-methylcarbamate) on the functions of T cells in splenocytes and peritoneal macrophages were examined in view of T-cell-mediated immune response (CMIR) in male C57BL/6 mice. Intraperitoneal administration of carbofuran (0.075, 0.15 and 0.3 mg/kg body weight) resulted in significant suppression of delayed type hypersensitivity (DTH), indicating that it caused the suppression of CMIR. Carbofuran decreased Concanavalin A (Con A)- and alloantigen-induced proliferation, and interleukin (IL)-2 production of splenocytes. In vitro addition of rIL-2 could not completely restore the suppressed T-cell proliferation, and IL-2-induced proliferation of Con A-activated splenocytes was also suppressed, which implied that carbofuran caused defects in IL-2 production and responsiveness of splenocytes to IL-2, leading to the suppression of T-cell proliferation. Con A-induced production of interferon-gamma (IFN-gamma) was significantly suppressed by carbofuran, while that of IL-4 was not affected. The production of transforming growth factor-beta from splenocytes was also significantly inhibited by carbofuran. Judging from these results, carbofuran might directly suppress the cytokine production in T helper 1 (Th1) cells. In addition, IFN-gamma -induced production
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