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In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma
- Issue Date
- Oct-1999
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Alismatis Rhizoma; Alismol; Alisol B monoacetate; Inducible nitric oxide synthase (iNOS); Inhibitor; RAW 264.7 cell
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.22, no.10, pp 1147 - 1149
- Pages
- 3
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 22
- Number
- 10
- Start Page
- 1147
- End Page
- 1149
- ISSN
- 0918-6158
1347-5215
- Abstract
- Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.
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