Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk
DC Field | Value | Language |
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dc.contributor.author | Katoh, T. | - |
dc.contributor.author | Inatomi, H. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Yang, M. | - |
dc.contributor.author | Matsumoto, T. | - |
dc.contributor.author | Kawamoto, T. | - |
dc.date.accessioned | 2022-04-19T13:21:58Z | - |
dc.date.available | 2022-04-19T13:21:58Z | - |
dc.date.issued | 1998-10 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.issn | 1872-7980 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150228 | - |
dc.description.abstract | The M1 member of the mu class of the glutathione S-transferase (GSTM1) gene is present in about 50% of individuals. GSTT1, a member of the theta class, which has been recently shown to be polymorphic, is expressed in 35-90% of individuals. In this study, 145 Japanese patients with urothelial transitional cell carcinoma and 145 healthy controls, frequency-matched for age and gender, were compared for frequencies of GSTM1 and GSTT1 genotypes. The urothelial cancer risk increased due to the GSTM1 null genotype (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.05-2.79). On the other hand, the OR tended to decrease due to the GSTT1 null genotype, although not significantly. Among individuals of the GSTM1 null genotype, those of the GSTT1-positive genotype had a two-fold risk (OR 2.62, 95% CI 1.36-5.05) compared with the GSTT1 null genotype (OR 1.25, 95% CI 0.62-2.51). A significant interaction between the GSTM1 genotype and smoking status was found; the GSTM1 null genotype was associated with an increased risk of urothelial cancer among smokers (OR 1.98, 95%CI 1.10-3.57). Copyright (C) 1998 Elsevier Science Ireland Ltd. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/S0304-3835(98)00183-9 | - |
dc.identifier.scopusid | 2-s2.0-0032561158 | - |
dc.identifier.wosid | 000077278500021 | - |
dc.identifier.bibliographicCitation | Cancer Letters, v.132, no.1-2, pp 147 - 152 | - |
dc.citation.title | Cancer Letters | - |
dc.citation.volume | 132 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 152 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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