LY-6K gene: A novel molecular marker for human breast cancer
- Authors
- Lee, Ji Woo; Lee, Yeon Su; Yoo, Kyung Hyun; Lee, Kee Ho; Park, Kyunghee; Ahn, Taejin; Ko, Christopher; Park, Jong Hoon
- Issue Date
- Dec-2006
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- human breast cancer; STS; Ly-6/uPAR superfamily; northern blot; RT-PCR
- Citation
- ONCOLOGY REPORTS, v.16, no.6, pp 1211 - 1214
- Pages
- 4
- Journal Title
- ONCOLOGY REPORTS
- Volume
- 16
- Number
- 6
- Start Page
- 1211
- End Page
- 1214
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15032
- ISSN
- 1021-335X
1791-2431
- Abstract
- A full-length cDNA was identified using one STS sequence containing an SNP (single nucleotide polymorphism) derived from genomic DNAs of breast cancer patients using a variety of bioinformatics tools. The cDNA encodes LY-6K, a novel member protein of the Ly-6/uPAR superfamily. It has been annotated as a target antigen for the HNSCC (head- and neck squamous cell carcinoma). We isolated the LY-6K gene from genomic DNAs obtained from breast cancer patients through large scale, case-control-screening. We performed Northern blot hybridization and semi-quantitative RT-PCR on a human multiple-tissue mRNA blot from several breast cancer patients. We investigated the expression level of the LY-6K gene in human breast cancer, and compared this to expression in human normal breast tissue. We found that LY-6K was more highly expressed in the mRNA of breast tumors compared to its expression in normal breast tissue. These results suggest that LY-6K is not only a target antigen for HNSCC but also a significant new molecular marker for diagnosis and gene therapy in patients with breast cancer.
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