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새로운 항암성 백금 ( II ) 착체류의 in vivo 독성연구General Toxicity of Novel Pt ( II ) Complexes in vivo
- Other Titles
- General Toxicity of Novel Pt ( II ) Complexes in vivo
- Issue Date
- Oct-1995
- Publisher
- 환경독성보건학회
- Citation
- Korean Journal of Environmental Toxicology (Environmental Analysis Health and Toxicology), v.10, no.3~4, pp 1 - 5
- Pages
- 5
- Journal Title
- Korean Journal of Environmental Toxicology (Environmental Analysis Health and Toxicology)
- Volume
- 10
- Number
- 3~4
- Start Page
- 1
- End Page
- 5
- ISSN
- 2093-6400
- Abstract
- The general toxicological study of new platinum(Ⅱ) compounds, KHPC-002, KHPC-005 and KHPC-006 were investigated in rats. The effects of these Pt(Ⅱ) complexes on renal, hematopoietic and hepatic system in rats showed lower toxicity compared with cisplatin. In the consideration of the maximal dose of these Pt(Ⅱ) complexes using in this experiment is 4-8 times higher than cisplatin, these novel compounds will have the less general toxicity in vivo.
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