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수종동물의 췌장조직내 NO Synthase 활성도 및 Methylarginines 함량NO Synthase Activities and Methylarginines Contents in the Pancreatic Tissues of Various Animals
- Other Titles
- NO Synthase Activities and Methylarginines Contents in the Pancreatic Tissues of Various Animals
- Issue Date
- Apr-1994
- Publisher
- 대한약학회
- Keywords
- Nitric oxide synthase; N G -monomethyl-L-arginine; N G , N G -dimethyl-L-arginine; N G , N ′ G -dimethyl-L-arginine
- Citation
- 약 학 회 지, v.38, no.2, pp 184 - 190
- Pages
- 7
- Journal Title
- 약 학 회 지
- Volume
- 38
- Number
- 2
- Start Page
- 184
- End Page
- 190
- ISSN
- 0377-9556
2383-9457
- Abstract
- The activities of nitric oxide synthase and the contents of methylarginines were investigated in the pancreatic tissues of various animals by citrulline-forming method and HPLC, respectively. The high level of in vitro NO synthase activity was detected in chicken pancreas whereas MMA, the strong competitive inhibitor for NO synthase, was detected as trace in the same tissue. On the other hand, the low level of NO synthase activity was observed in the porcine pancreas while the contents of MMA were high. However, it was not possible to find any relationship between NO synthase activities and the contents of dimethylarginines at present time. D'MA was equally distributed among the pancreatic tissues of various animals but DMA was not.
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