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Inhibitory effect of papaverine on the contraction induced by transmural stimulation in the isolated mouse vas deferens

Authors
Park, E.-H.Song, Y.S.
Issue Date
Jun-1992
Publisher
Pharmaceutical Society of Korea
Keywords
acetylcholine; adrenergic neurotransmission; mouse vas deferens; noradrenaline; Papaverine
Citation
Archives of Pharmacal Research, v.15, no.2, pp 134 - 137
Pages
4
Journal Title
Archives of Pharmacal Research
Volume
15
Number
2
Start Page
134
End Page
137
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151148
DOI
10.1007/BF02974088
ISSN
0253-6269
1976-3786
Abstract
The effect of papaverine on the contractions induced by adrenergic neurotransmission in the isolated mouse vas deferens was investigated. Papaverine, 10-10M, showed a dose-dependent and reversible inhibition on the induced contractions. When the frequency of stimulation was varied (2.5-20.0 Hz), the inhibitory effect tended to be marked at the lower frequencies.
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