한국산 배(梨)를 중심한 과수의 기능성 연구

Abstract

In my previous study, consumption of Korean pears had inverse association with level of urinary 1-hydroxypyrene (1-OHP), which is an exposure biomarker and metabolite of polycyclic aromatic hydrocarbons (PAHs). Bioproduction of reactive intermediate of PAHs or induction of oxidative stress have been suspected as the mechanisms of PAHs-related diseases such as lung cancer, asthma, etc. Thus, to clarify potential of functional food in the Korean pears against PAHs-exposure, I studied effects of the Ko rean pears on 1. PAHstoxicokinetics, 2. PAHs- induced oxidative stress in intervention trials (N=30; male, N=10; female, N=20), and 3. PAHs- related chronic obstructive pulmonary disease (COPD: N= 30). The intake of Bulgogi, Korean barbeque, was used as exposure to PAHs. After 3 Ieks trials for the same subjects (1 week for Bulgogi only, Bulgogi with the pears, and the pears only, respectively), I found rapid excretion of urinary 1-OHP with the pears during 24 hrs compared to that without pears (0.05 In conclusion, my results suggest that the Korean pears have chemoprevention effects on PAHs- induced carcinogenic mechanisms due to rapid excretion of PAHs- intermediates and reduction of PAHs- induced oxidative stress. However, the pear-chemopreventive effects against PAHs-related diseases should be further clarified in enlarged population studies.