Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants
DC Field | Value | Language |
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dc.contributor.author | Park, J | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Kim, TS | - |
dc.date.available | 2021-02-22T15:31:06Z | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.issn | 1879-0542 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15163 | - |
dc.description.abstract | Apigenin, a flavonoid present in many dietary plants, exhibits anti-allergic activity and inhibits IL-4 production by basophils and mast cells. However, the mechanism by which apigenin suppresses IL-4 production especially in T cells remains unclear. In this study, the effect of apigenin and its underlying mechanism on IL-4 production were investigated in activated T cells. Apigenin significantly inhibited IL-4 production in both EL4 T thymoma cells and primary lymph node cells. Apigenin also inhibited IL-4 gene promoter activity in EL4 cells transiently transfected with IL-4 gene promoter constructs, but this inhibitory effect was impaired in EL4 cells transfected with an IL-4 promoter construct deleted of NF-AT binding sites. In addition, apigenin inhibited NF-AT DNA binding activities, indicating that apigenin may inhibit IL-4 production in T cells via down-regulation of NF-AT DNA binding activity. (C) 2005 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.imlet.2005.10.002 | - |
dc.identifier.scopusid | 2-s2.0-31544477689 | - |
dc.identifier.wosid | 000235700000005 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.103, no.2, pp 108 - 114 | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 103 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 108 | - |
dc.citation.endPage | 114 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR GATA-3 | - |
dc.subject.keywordPlus | HUMAN IL-4 PROMOTER | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NUCLEAR FACTOR | - |
dc.subject.keywordPlus | TH2 CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | LUTEOLIN | - |
dc.subject.keywordPlus | MURINE | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | CALCINEURIN | - |
dc.subject.keywordAuthor | apigenin | - |
dc.subject.keywordAuthor | interleukin-4 | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordAuthor | allergy | - |
dc.subject.keywordAuthor | NF-AT | - |
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