Biocompatible 7-nitro-2,1,3-benzoxadiazole-embedded naphthalimide for exploring endogenous H2S in living cells
DC Field | Value | Language |
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dc.contributor.author | Yoon, Shin A. | - |
dc.contributor.author | Gopala, Lavanya | - |
dc.contributor.author | Lee, Min Hee | - |
dc.date.accessioned | 2023-11-08T05:47:55Z | - |
dc.date.available | 2023-11-08T05:47:55Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1386-1425 | - |
dc.identifier.issn | 1873-3557 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151697 | - |
dc.description.abstract | Hydrogen sulfide (H2S) is a central signaling and antioxidant biomolecule involved in various biological processes. As inappropriate levels of H2S in the human body are closely related to various diseases, including cancer, a tool capable of detecting H2S with high selectivity and sensitivity in living systems is urgently required. In this work, we intended to develop a biocompatible and activatable fluorescent molecular probe for detecting H2S generation in living cells. The 7-nitro-2,1,3-benzoxadiazole-imbedded naphthalimide (1) probe presented here responds specifically to H2S and produces readily detectable fluorescence at 530 nm. Interestingly, probe 1 exhibited significant fluorescence responses to changes in endogenous H2S levels as well as high biocompatibility and permeability in living HeLa cells. This allowed for the real-time monitoring of endogenous H2S generation as an antioxidant defense response in the oxidatively stressed cells. © 2023 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Biocompatible 7-nitro-2,1,3-benzoxadiazole-embedded naphthalimide for exploring endogenous H2S in living cells | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.saa.2023.122582 | - |
dc.identifier.scopusid | 2-s2.0-85149769746 | - |
dc.identifier.wosid | 001007276000001 | - |
dc.identifier.bibliographicCitation | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, v.295 | - |
dc.citation.title | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | - |
dc.citation.volume | 295 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | HYDROGEN-SULFIDE | - |
dc.subject.keywordPlus | FLUORESCENT-PROBE | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordAuthor | 7-Nitro-2,1,3-benzoxadiazole-embedded naphthalimide | - |
dc.subject.keywordAuthor | Antioxidant defense responses | - |
dc.subject.keywordAuthor | Biocompatible fluorescent probe | - |
dc.subject.keywordAuthor | Hydrogen sulfide | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1386142523002676?via%3Dihub | - |
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