Biocompatible 7-nitro-2,1,3-benzoxadiazole-embedded naphthalimide for exploring endogenous H2S in living cells
- Authors
- Yoon, Shin A.; Gopala, Lavanya; Lee, Min Hee
- Issue Date
- Jul-2023
- Publisher
- Elsevier B.V.
- Keywords
- 7-Nitro-2,1,3-benzoxadiazole-embedded naphthalimide; Antioxidant defense responses; Biocompatible fluorescent probe; Hydrogen sulfide
- Citation
- Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, v.295
- Journal Title
- Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
- Volume
- 295
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/151697
- DOI
- 10.1016/j.saa.2023.122582
- ISSN
- 1386-1425
1873-3557
- Abstract
- Hydrogen sulfide (H2S) is a central signaling and antioxidant biomolecule involved in various biological processes. As inappropriate levels of H2S in the human body are closely related to various diseases, including cancer, a tool capable of detecting H2S with high selectivity and sensitivity in living systems is urgently required. In this work, we intended to develop a biocompatible and activatable fluorescent molecular probe for detecting H2S generation in living cells. The 7-nitro-2,1,3-benzoxadiazole-imbedded naphthalimide (1) probe presented here responds specifically to H2S and produces readily detectable fluorescence at 530 nm. Interestingly, probe 1 exhibited significant fluorescence responses to changes in endogenous H2S levels as well as high biocompatibility and permeability in living HeLa cells. This allowed for the real-time monitoring of endogenous H2S generation as an antioxidant defense response in the oxidatively stressed cells. © 2023 Elsevier B.V.
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