Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues
- Authors
- Lee, HJ; Kim, JS; Yoon, JW; Kim, HD; Ryu, JH
- Issue Date
- Mar-2006
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- nitric oxide; yakuchinone analogues; inhibitor; iNOS; expression
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.54, no.3, pp 377 - 379
- Pages
- 3
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 54
- Number
- 3
- Start Page
- 377
- End Page
- 379
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15174
- DOI
- 10.1248/cpb.54.377
- ISSN
- 0009-2363
1347-5223
- Abstract
- Analogues of yakuchinones were synthesized as inhibitors of nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells. We prepared stronger inhibitors than the original natural molecules, yakuchinones A and B reported from Alpinia oxyphylla. From the limited structural activity relation study of analogues, we concluded that the optimal length of linker between two aryl groups and the presence of enone moiety in the linker were identified as essential for the activity. The IC50 value of the most potent structure was 0.92 mu M. The active analogues suppressed the expression of inducible nitric oxide synthase protein and mRNA.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.