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시차열량분석기를 이용한 온도 민감성 리포좀의 제조Preparation of Temperature-Sensitive Liposomes Using Differential Scanning Calorimetiy
- Other Titles
- Preparation of Temperature-Sensitive Liposomes Using Differential Scanning Calorimetiy
- Authors
- 김진석
- Issue Date
- Feb-2006
- Publisher
- 숙명여자대학교 약학연구소
- Citation
- 약학논문집-숙명여자대학교, v.23, pp 46 - 49
- Journal Title
- 약학논문집-숙명여자대학교
- Volume
- 23
- Start Page
- 46
- End Page
- 49
- ISSN
- 1225-3723
- Abstract
- New temperature-sensitive liposomes, which show a transition temperature around 41°C, were prepared using a differential scanning calorimetry method. Various compositions of phospholipids with or without encapsulated drug were tested and DPPC:DMPC:DSPC (4:1:1 molar ratio) liposome was found to have a transition temperature of 41°C from solid gel state to liquid crystalline state, which might be useful for targeting of anticancer drugs or radio-sensitizers to the tumor or inflammation sites.
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