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Analysis of protein redox modification by hypoxia
- Authors
- Choi, Kyoung-Soo; Park, Soo-Yeon; Baek, Sun-Hee; Dey-Rao, Rama; Park, Young-Mee; Zhang, Haitao; Ip, Clement; Park, Eun-Mi; Kim, Yeul Hong; Park, Jong Hoon
- Issue Date
- Feb-2007
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- hypoxia; oxidative stress; redox modification; proteomics
- Citation
- PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v.36, no.1, pp 65 - 79
- Pages
- 15
- Journal Title
- PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Volume
- 36
- Number
- 1
- Start Page
- 65
- End Page
- 79
- ISSN
- 1082-6068
1532-2297
- Abstract
- We examined hypoxia-induced changes in global thiol proteome profile in human prostate cancer cells using a BIAM-based display method. We analyzed the kinetics of protein thiol modification by using a pattern recognition algorithm, self-organizing maps (SOM) clustering, and identified the BIAM-labeled proteins by MALDI-TOF and ESI-tandem mass spectrometry. We found 99 out of 215 of total BIAM-labeled proteins were affected by hypoxia treatment and, yet, with diverse patterns and kinetics of redox modification. Our study proved that proteomics analysis employing the BIAM-labeling method can provide valuable information pertaining to global changes in the redox status of proteins in response to hypoxia.
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