이온토포레시스에 의한 경피 투과도 조절

Abstract

We have prepared hydrophilic karaya gum patches containing ketoprofen and studied some important factors which affect the transdermal flux of ketoprofen, as a first step to develop an iontophoretic transdermal patch system. The effect of penetration enhancer (propylene glycol monolaurate: PGML), short-time current treatment and continuous current on flux was studied. The effect of pH of the receptor solution and poly (L-lysine) (PLL) was also studied. PGML increased the passive flux markedly, and as the concentration of PGML in the matrix increased, passive flux increased. Iontophoretic treatment of skin (0.4 mA/cm²) for an hour increased the average passive flux more than two times, when the matrix contained no enhancer. It also increased the average passive flux further, when enhancer was incorporated into the matrix. Continuous iontophoretic transport showed unexpected result; the average flux at 0.2 mA/cm² was similar to that at 0.4 mA/cm², and was higher than that at 0.6 mA/cm². PLL increased the continuous iontophoretic transport at all current density, and the average flux was higher at 0.6 mA/cm² than at 0.4 and 0.2 mA/cm². Similar results were obtained when the receptor solution was changed to pH 4.0 buffer solution. These result demonstrate, that electro-osmotic flow is playing an important role in the flux of ketoprofen.