한국인에서 DPD 및 TS, MTHFR의 유전자다형
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양미희 | - |
dc.date.available | 2021-02-22T16:01:52Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 1225-3723 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15825 | - |
dc.description.abstract | In-order to do efficient treatment of 5-Fluorouracil (5-FU) in Koreans, we investigated genetic polymorphisms of dihydropyrimidine dehydrogenase (DPD; gene, DPYD), thymidylate synthase (75), and methyltetrahydrofolate reductase (MTHFR), which are involved in 5- FU metabolism or efficacy in a Korean population. As results, we found genetic polymorphisms in DPYD-85, -1627, and -1896 site, TS-5'ER, and -3'U'TR, and MTHFR-222, 429 site among the Koreans (normal, N=105; head and neck cancer patients, N=28). 5-FU efficacy was determined into PR(partial response, decrease of cancer size over 50%) and SD (stable disease). Each or combination of the above 7 genetic polymorphisms were not associated with 5-FU efficacy. Therefore, the studied 7 genotypes can not be considered to result in individual variation in 5-FU efficacy. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 숙명여자대학교 약학연구소 | - |
dc.title | 한국인에서 DPD 및 TS, MTHFR의 유전자다형 | - |
dc.type | Article | - |
dc.publisher.location | South Korea | - |
dc.identifier.bibliographicCitation | 약학논문집-숙명여자대학교, v. 21, pp 114 - 120 | - |
dc.citation.title | 약학논문집-숙명여자대학교 | - |
dc.citation.volume | 21 | - |
dc.citation.startPage | 114 | - |
dc.citation.endPage | 120 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | domestic | - |
dc.identifier.url | http://www.riss.kr/search/detail/DetailView.do?p_mat_type=1a0202e37d52c72d&control_no=52389686f092ab5dffe0bdc3ef48d419 | - |
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