노화에 의한 콜린과 타우린의 뇌수송에 대한 변화The Change on Brain Transport of Choline and Taurine by Aging
- Other Titles
- The Change on Brain Transport of Choline and Taurine by Aging
- Authors
- 강영숙
- Issue Date
- Feb-2004
- Publisher
- 숙명여자대학교 약학연구소
- Citation
- 숙명여자대학교 약학논문집, v.20, pp 37 - 41
- Journal Title
- 숙명여자대학교 약학논문집
- Volume
- 20
- Start Page
- 37
- End Page
- 41
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15906
- ISSN
- 1225-3723
- Abstract
- The blood-brain barrier (BBB) permeability of [^(J)H]choline and [³H]taurine was compared in senescence-accelerated mouse(SAM) and normal mouse (ICR) with common carotid artery perfusion (CCAP) method to establish a possible relation between aging and changes in brain transport of choline and taurine. The SAM strains developed as the animal model show senescence acceleration and age-associated pathological phenotypes similar to geriatric disorders seen in humans. Futhermore choline plays a key role in function of biological membrane and as a precursor for the synthesis of acetylcholine related with Alzheimer's disease or dementia. Taurine is also known to have a neuroprotective effect against oxidative stress and excito-toxic agents. As the result of the experiments, the brain volume of distribution (V_(D,brain)) of [³H]choline in SAM by CCAP method increased about 4-fold compared with that in normal mice while V_(D,brain) of [³H]taurine in SAM was reduced by 85%. These results suggest that aging may bring about changes on the brain transport activity of choline and taurine through the BBB.
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