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Protein Phosphatase Inhibitor-1 has protective activities in stress conditions in E.coli
- Authors
- Thomas Doohun Kim
- Issue Date
- Feb-2006
- Publisher
- Elsevier
- Citation
- International Journal of Biological Macromolecules, v.38, no.1, pp 70 - 76
- Pages
- 7
- Journal Title
- International Journal of Biological Macromolecules
- Volume
- 38
- Number
- 1
- Start Page
- 70
- End Page
- 76
- ISSN
- 0141-8130
1879-0003
- Abstract
- Protein phosphatase inhibitor-1 (PPI-1) is a major inhibitor of protein phosphatase 1 (PPI), which regulates signal transduction in many eukaryotic cellular processes. Biophysical studies have shown that PPI-1 has a large Stokes radius and is heat stable, Suggesting that it lacks extensive secondary structures. The unfolded structure of PPI-1 may enable it to interact with many proteins or ligands during stress conditions. Here we show that PPI-1 can act as a protective molecule, inhibiting protein aggregation and guarding E. coli cells against various stresses. Therefore, PPI-1 seems to have a physiological function as a protective molecule as well as regulator of protein serine/threonine phosphatases. (c) 2006 Elsevier B.V. All rights reserved.
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