Mobile Efficient Diagnostics of Infectious Diseases via On-Chip RT-qPCR: MEDIC-PCRopen access
- Authors
- Shrestha, Kiran; Kim, Seongryeong; Han, Jiyeon; Florez, Gabriela Morales; Truong, Han; Hoang, Trung; Parajuli, Sajjan; Tiara, A. M.; Kim, Beomsoo; Jung, Younsu; Abafogi, Abdurhaman Teyib; Lee, Yugyeong; Song, Seung Hyun; Lee, Jinkee; Park, Sungsu; Kang, Minhee; Huh, Hee Jae; Cho, Gyoujin; Lee, Luke P.
- Issue Date
- Oct-2023
- Publisher
- WILEY
- Keywords
- covid-19; diagnostics; low-cost; rapid; rt-qpcr
- Citation
- ADVANCED SCIENCE, v.10, no.28
- Journal Title
- ADVANCED SCIENCE
- Volume
- 10
- Number
- 28
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159737
- DOI
- 10.1002/advs.202302072
- ISSN
- 2198-3844
2198-3844
- Abstract
- The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, the authors use a roll-to-roll printing process to accomplish low-cost carbon-black-based disposable PCR chips that enable rapid LED-induced photothermal PCR cycles. The MEDIC-PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID-19 and 103 non-COVID-19 patients testing is completed by the MEDIC-PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC-PCR can contribute to the preventive global health in the face of a future pandemic.
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