Effect of Silicone Patch Containing Metal-organic Framework on Hypertrophic Scar Suppressionopen access
- Authors
- Zhang, Xin Rui; Ryu, Unjin; Najmiddinov, Bakhtiyor; Trinh, Thuy-Tien Thi; Choi, Kyung Min; Nam, Sun-Young; Heo, Chan Yeong
- Issue Date
- Jan-2024
- Publisher
- International Institute of Anticancer Research
- Keywords
- alpha-smooth muscle actin (α- SMA); Hypertrophic scar; metal-organic frameworks (MOF); myofibroblasts; silicone patch; transforming growth factor β1 (TGF- β1); Zr-MOF-808
- Citation
- In vivo (Athens, Greece), v.38, no.1, pp 235 - 245
- Pages
- 11
- Journal Title
- In vivo (Athens, Greece)
- Volume
- 38
- Number
- 1
- Start Page
- 235
- End Page
- 245
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159841
- DOI
- 10.21873/invivo.13430
- ISSN
- 0258-851X
1791-7549
- Abstract
- BACKGROUND/AIM: Hypertrophic scars (HS) are an abnormal cutaneous condition of wound healing characterized by excessive fibrosis and disrupted collagen deposition. This study assessed the potential of a silicone patch embedded with chemically stable zirconium-based metal-organic frameworks (MOF)-808 structures to mitigate HS formation using a rabbit ear model. MATERIALS AND METHODS: A silicone patch was strategically engineered by incorporating Zr-MOF-808, a composite structure comprising metal ions and organic ligands. Structural integrity of the Zr-MOF-808 silicone patch was validated using scanning electron microscopy and X-ray diffraction analysis. The animals were divided into three groups: a control, no treatment group (Group 1), a silicone patch treatment group (Group 2), and a group treated with a 0.2% loaded Zr-MOF-808 silicone patch (Group 3). HS suppression effects were quantified using scar elevation index (SEI), dorsal skin thickness measurements, and myofibroblast protein expression. RESULTS: Histopathological examination of post-treatment HS samples revealed substantial reductions in SEI (34.6%) and epidermal thickness (49.5%) in Group 3. Scar hyperplasia was significantly diminished by 53.5% (p<0.05), while collagen density declined by 15.7% in Group 3 compared to Group 1. Western blot analysis of protein markers, including TGF-β1, collagen-1, and α-SMA, exhibited diminished levels by 8.8%, 12%, and 21.3%, respectively, in Group 3, and substantially higher levels by 21.9%, 27%, and 39.9%, respectively, in Group 2. On the 35th day post-wound generation, Zr-MOF-808-treated models exhibited smoother, less conspicuous, and flatter scars. CONCLUSION: Zr-MOF-808-loaded silicone patch reduced HS formation in rabbit ear models by inducing the proliferation and remodeling of the wound healing process.
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