IL-1/Toll-like Receptor Superfamily 신호전달에 관여하는 TRAF6 결합 Motif의 규명Identification of TRAF6-Binding Motif in IL-1/Toll-like Receptor Superfamily-Mediated Signal Transduction
- Other Titles
- Identification of TRAF6-Binding Motif in IL-1/Toll-like Receptor Superfamily-Mediated Signal Transduction
- Authors
- 임미정
- Issue Date
- Jun-2003
- Publisher
- 대한약학회
- Citation
- 약 학 회 지, v.47, no.3, pp 180 - 183
- Pages
- 4
- Journal Title
- 약 학 회 지
- Volume
- 47
- Number
- 3
- Start Page
- 180
- End Page
- 183
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16320
- ISSN
- 0377-9556
- Abstract
- Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD4O was previously determined. The structure revealed a distinct TRAF6-binding groove of CD4O, the key structural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the hIRAK protein, whose functional requirement in IL-1/Toll-like eceptor superfamilies-mediated signal transduction is further demonstrated using site- directed mutagenesis. The mutational effects of MRAK on the down-stream NF-KB signaling shows the importance of the TRAF6 interface for signaling by IL-1/Toll-like receptor superfamilies.
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