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Synthesis and biological evaluation of some new substituted naphthoquinones
- Authors
- Habib N.S.; Bekhit A.A.; Park J.Y.
- Issue Date
- Jun-2003
- Publisher
- Societa Editoriale Farmaceutica
- Keywords
- Acute toxicity; Anticancer activity; Antimicrobial activity; Naphthoquinone derivatives
- Citation
- Bollettino Chimico Farmaceutico, v.142, no.5, pp 232 - 238
- Pages
- 7
- Journal Title
- Bollettino Chimico Farmaceutico
- Volume
- 142
- Number
- 5
- Start Page
- 232
- End Page
- 238
- ISSN
- 0006-6648
- Abstract
- Two novel series of 1,4-naphthoquinone derivatives have been synthesized namely; N-ethoxycarbonyl-2-ethoxycarbonyloxy-3-alkyl-1,4-naphthoquinon-1-substituted phenylhydrazones 3a-f and 2-chlorocetyloxy-3-alkyl-1,4-naphthoquinone-1- substituted phenylhydrazones 4a-d. The antimicrobial activity as well as anticancer activity of these compounds have been evaluated. The acute toxicity of the active compounds was determined.
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