The Glu/Asp polymorphism of ecNOS gene and the renal progression in Korean autosomal dominant polycystic kidney disease (ADPKD) patients
- Authors
- Lee, JG; Ahn, C; Yoon, SC; Park, JH; No, JJ; Moon, CS; Song, EK; Hwang, YH; Hwang, DY; Kim, YS; Han, JS; Kim, SG; Lee, JS; Kim, SH
- Issue Date
- Sep-2002
- Publisher
- 한국유전학회
- Keywords
- autosomal dominant polycystic kidney disease (ADPKD); ecNOS; Glu298Asp polymorphism; Korean
- Citation
- Genes & Genomics, v.24, no.3, pp 241 - 246
- Pages
- 6
- Journal Title
- Genes & Genomics
- Volume
- 24
- Number
- 3
- Start Page
- 241
- End Page
- 246
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16397
- ISSN
- 0254-5934
- Abstract
- Two genetic loci, PKD1 and PKD2, have been identified as being responsible for ADPKD, but the presence of an intrafamilial clinical diversity suggests that there are disease-modifying loci. We studied the associations between polymorphism in the ecNOS gene, which are known to be associated with chronic tubulointerstitial and vascular changes, and ADPKD progression in Korean patients. A total of 112 individuals who had ADPKD and 41 normal control subjects were genotyped by PCR-RFLP, the Glu298Asp variant of ecNOS gene was discriminated with MboI. The distribution of the alleles for the ecNOS Glu298Asp polymorphism in ADPKD was: G 88%, T 12%, which was similar to the result of Korean population (95: 5, p = 0.128) but different from Western controls (65: 35, p = 0.000). No differences were found between the CRF and the non-CRF groups (p = 1.000) or the early hypertension and the normotension groups (p = 1.000). In conclusion, our results suggest that the polymorphism at Glu298Asp of ecNOS has no association with the renal progression in Korean ADPKD patients.
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