Effects of Polygonatum odoratum on mercuric chloride induced renal failure rats

Abstract

The rhizoma of Polygonatum odoratum (Liliaceae) has been used as the treatment of body fluid deficiency, dryness symptoms and hyper glycemia. To study effects on acute renal failure of P. odorati rhizoma, urinary volume, urinary electrolytes and serum factors associated with renal dysfunction were measured in HgCl2-induced acute renal failure rats. It was revealed that its ether ex. had significant diuretic effects, regulated hypoelectrolytes(Na+, K+, Cl-) and inhibited the increase of creatinine, BUN in acute renal failure rats. From the ether ex. which was more effective than MeOH ex., three lipophilic compounds were isolated and elucidated hydrocarbon(1), β-sitosteryl stearate(2), β-sitosterol(3). The β-sitosteryl stearate(2) were isolated from Polygonatum sp. at first.