Analysis of mitochondrial DNA mutation in hepatoma
- Authors
- Chung, KS; Lee, KY; Shim, SI; Kim, J; Song, E
- Issue Date
- Sep-2000
- Publisher
- SPRINGER-VERLAG SINGAPORE PTE LTD
- Keywords
- mtDNA deletion; hepatoma; coxIII; in situ hybridization; PCR
- Citation
- JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.33, no.5, pp 417 - 421
- Pages
- 5
- Journal Title
- JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Volume
- 33
- Number
- 5
- Start Page
- 417
- End Page
- 421
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16738
- ISSN
- 1225-8687
- Abstract
- Mitochondrial DNA (mtDNA) mutation was investigated in a hepatoma patient using a polymerase chain reaction (PCR) and an in situ hybridization technique. Biotin-labeled probes for the subunit III of cytochrome c oxidase revealed differences in the in situ hybridization. A PCR assay using biopsied and microdissected tissues showed that common deletion (4,977 bp) was more pronounced in the cancer region than in the normal parts of the same patient. These results suggest that mtDNA deletion might be associated with tumorigenesis in hepatoma.
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