Detailed Information

Cited 0 time in webofscience Cited 7 time in scopus
Metadata Downloads

PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation

Authors
Kim, SeulKim, Nam HyunPark, Ji EunHwang, Jee WonMyung, NayeonHwang, Ki-TaeKim, Young A.Jang, Chang-YoungKim, Yong Kee
Issue Date
Jan-2020
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.11, no.1
Journal Title
NATURE COMMUNICATIONS
Volume
11
Number
1
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1683
DOI
10.1038/s41467-020-14511-w
ISSN
2041-1723
Abstract
The kinase Aurora B forms the chromosomal passenger complex (CPC) together with Borealin, INCENP, and Survivin to mediate chromosome condensation, the correction of erroneous spindle-kinetochore attachments, and cytokinesis. Phosphorylation of histone H3 Thr3 by Haspin kinase and of histone H2A Thr120 by Bub1 concentrates the CPC at the centromere. However, how the CPC is recruited to chromosome arms upon mitotic entry is unknown. Here, we show that asymmetric dimethylation at Arg2 on histone H3 (H3R2me2a) by protein arginine methyltransferase 6 (PRMT6) recruits the CPC to chromosome arms and facilitates histone H3S10 phosphorylation by Aurora B for chromosome condensation. Furthermore, in vitro assays show that Aurora B preferentially binds to the H3 peptide containing H3R2me2a and phosphorylates H3S10. Our findings indicate that the long-awaited key histone mark for CPC recruitment onto mitotic chromosomes is H3R2me2a, which is indispensable for maintaining appropriate CPC levels in dynamic translocation throughout mitosis. The proteins of the chromosomal passenger complex help chromosomes condense before cell division, but how this complex arrives at chromosomes was not known. Here the authors show that PRMT6 methylates histone H3 to recruit the chromosomal passenger complex.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yong Kee photo

Kim, Yong Kee
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE