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케토프로펜-폴리에틸렌글리콜 전구약물의 합성 및 가수분해Synthesis and Hydrolysis of Ketoprofen Prodrug Conjugated to Poly(Ethylene Glycol)
- Other Titles
- Synthesis and Hydrolysis of Ketoprofen Prodrug Conjugated to Poly(Ethylene Glycol)
- Issue Date
- Mar-2003
- Publisher
- 한국약제학회
- Citation
- Journal of Pharmaceutical Investigation, v.33, no.1, pp 37 - 43
- Pages
- 7
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 33
- Number
- 1
- Start Page
- 37
- End Page
- 43
- ISSN
- 2093-5552
2093-6214
- Abstract
- The objective of this study is to prepare ketoprofen (KP) - poly(ethylene glycol) (PEG) conjugates and to investigate their degradation kinetics. KP-PEG conjugates were synthesized from KP and PEG methylester by esterification in the presence of DCC. The KP-PEG conjugates (KPEG) were characterized by IR and ^1H-NMR spectroscopy. The hydrolysis of KPEG with time was studied using HPLC by simultaneous quantification of KP and KPEG. The hydrolysis rate constant was high at low and high pHs, and showed minimum at pH 4 and 5. As the size of KPEG increase, hydrolysis rate increased. The slope of degradation rate profile suggests that catalytic reaction seems to occur by specific acid/base catalysis. These results suggest that KPEG could be used as a prodrug for KP, which releases KP slowly in the body.
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