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유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과Synthesis of Urea and Thiourea Derivatives and Their Inhibitory Activities of NO Productionby Activated Macrophages
- Other Titles
- Synthesis of Urea and Thiourea Derivatives and Their Inhibitory Activities of NO Productionby Activated Macrophages
- Issue Date
- Aug-2007
- Publisher
- 대한약학회
- Keywords
- urea; thiourea; nitric oxide; iNOS; indole; benzoxazole
- Citation
- 약 학 회 지, v.51, no.4, pp 246 - 252
- Pages
- 7
- Journal Title
- 약 학 회 지
- Volume
- 51
- Number
- 4
- Start Page
- 246
- End Page
- 252
- ISSN
- 0377-9556
- Abstract
- Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 μM of IC50 value.
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