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Synthesis and biological evaluation of pyrimidine nucleosides fused with 3 ',4 '-tetrahydrofuran ring
- Issue Date
- Oct-2003
- Publisher
- MARCEL DEKKER INC
- Citation
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.22, no.5-8, pp 719 - 721
- Pages
- 3
- Journal Title
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Volume
- 22
- Number
- 5-8
- Start Page
- 719
- End Page
- 721
- ISSN
- 1525-7770
- Abstract
- Pyrimidine nucleosides fused with 3,4'-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue 1 and its corresponding 2'-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.
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