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Estrogen Receptor-Mediated Transcriptional Activities of Spent Coffee Grounds and Spent Coffee Grounds Compost, and Their Phenolic Acid Constituents

Authors
An, Byoung HaJeong, HyesooKim, Jin-HeePark, SujeongJeong, Jin-HyunKim, Min JungChang, Minsun
Issue Date
Aug-2019
Publisher
AMER CHEMICAL SOC
Keywords
spent coffee grounds; spent coffee grounds compost; phenolic acids; 5-O-caffeoylquinic acid; estrogen receptors; endocrine disrupting chemical
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.67, no.31, pp.8649 - 8659
Journal Title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume
67
Number
31
Start Page
8649
End Page
8659
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2931
DOI
10.1021/acs.jafc.9b02452
ISSN
0021-8561
Abstract
Spent coffee grounds (SCG) are the most abundant coffee byproduct and are generally discarded as waste. The horticultural use of SCG and SCG compost (SCGC) has become popular due to a growing interest in environmentally friendly measures for waste disposal. Estrogen-like endocrine disrupting chemicals in the soil can be absorbed by plants and subsequently by humans who consume these plants. The objectives of this study are to determine the phytochemical profiles of extracts of SCG and SCGC and to evaluate the estrogen-like activities of SCG, SCGC, and the major coffee phenolic acids, specifically, 5-O-caffeoylquinic acid (CQA), caffeic acid, and ferulic acid. Their inductive effects on estrogen receptor (ER)-mediated gene transcription have been examined in cultured cell lines. CQA was the most abundant phenolic acid in SCG and SCGC and was further examined for its ER-mediated estrogen-like activity using various assays. This is the first study to report the estrogen-like signaling activities of coffee byproducts and their major constituents.
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