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Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway
- Authors
- Moon, Sung Ung; Park, Yongkeun; Park, Min Geun; Song, Sung Kyu; Jeong, Seok Hoo; Lee, Yong Seung; Heo, Hye Jung; Jung, Woon Yong; Kim, Soonhag
- Issue Date
- Jul-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.55, no.52, pp 7466 - 7469
- Pages
- 4
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 55
- Number
- 52
- Start Page
- 7466
- End Page
- 7469
- ISSN
- 1359-7345
1364-548X
- Abstract
- We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5-fluorouracil by hybridization with miR-141-3p, which is applicable to cancer treatment.
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