Analysis and comparison of statin prescription patterns and outcomes according to clinical department
- Authors
- Kim, H. -S.; Kim, H.; Lee, H.; Park, B.; Park, S.; Lee, S. -H.; Cho, J. H.; Song, H.; Kim, J. H.; Yoon, K. -H.; Choi, I. Y.
- Issue Date
- Feb-2016
- Publisher
- Blackwell Publishing Inc.
- Keywords
- HMG-CoA reductase inhibitor (statin); Hypercholesterolaemia; LDL-cholesterol; target achievement rate; treatment gap
- Citation
- Journal of Clinical Pharmacy and Therapeutics, v.41, no.1, pp 70 - 77
- Pages
- 8
- Journal Title
- Journal of Clinical Pharmacy and Therapeutics
- Volume
- 41
- Number
- 1
- Start Page
- 70
- End Page
- 77
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3573
- DOI
- 10.1111/jcpt.12350
- ISSN
- 0269-4727
1365-2710
- Abstract
- What is known and objectiveThere is a disparity between the Korean treatment guidelines and actual clinical prescription habits. This study was designed to evaluate the department-specific disparities and achievement rates for low-density lipoprotein cholesterol (LDL-C) targets, based on each department's specific statin prescription patterns. MethodsWe retrospectively evaluated data from 31718 patients who had been prescribed a statin at least once between January 2008 and June 2013 at our institution. Patients were classified into the high-risk (target LDL-C<100mg/dL) or moderate-risk (target LDL-C<130mg/dL) groups, according to the National Cholesterol Education Programme-Adult Treatment PanelIII guidelines. Results and discussionStatins were most commonly prescribed in the cardiology (320%) and endocrinology (266%) departments. For the high-risk group, 70% of patients in the cardiology, endocrinology and cardiac surgery departments achieved their target LDL-C levels (<100mg/dL). However, the target achievement rates in most other departments were <70%. For the moderate-risk group, 792% of patients achieved their target levels. Departments that prescribed a greater number of high- or intermediate-potency statins were more likely to achieve their target LDL-C levels. The group that achieved their target LDL-C levels (<100mg/dL) exhibited a significant positive relationship (Spearman's correlation coefficient=08571, P=00065), from low to high potency. What is new and conclusionSome departments tend to undertreat when prescribing statins. However, to reach to the target LDL-C levels, physicians must overcome their tendency to undertreat with statins. We believe that the target achievement rate will increase if doctors are more actively aware of a patient's individual status and related risk factors before prescribing statins.
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