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Erythroid differentiation regulator 1 strengthens TCR signaling in thymocytes by modulating calcium flux

Authors
Kim, Myun SooLee, SoraJung, Su-JinPark, SunyoungKim, Kyung EunKim, Tae SungPark, Hyun JeongCho, Daeho
Issue Date
Feb-2019
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Erdr1; Thymocyte; TCR; Calcium flux
Citation
CELLULAR IMMUNOLOGY, v.336, pp.28 - 33
Journal Title
CELLULAR IMMUNOLOGY
Volume
336
Start Page
28
End Page
33
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3821
DOI
10.1016/j.cellimm.2018.12.004
ISSN
0008-8749
Abstract
Erythroid differentiation regulator 1 (Erdr1) has been identified as a stromal survival factor released under stressful conditions. Previously, Erdr1 was reported to be expressed highly in thymus, but roles of Erdr1 in thymus were not known. Here, the effects of Erdr1 on T cell development were investigated. The expression of Erdr1 was higher in thymus than bone marrow and Erdr1 was detected in both the cortex and medulla of thymus. Erdr1 treatment significantly induced the expression of activation marker, CD69, from thymocytes in the presence of TCR stimuli in vitro and the induction was dependent on increased Ca2+ influx. In addition, in vivo administration of Erdr1 resulted in significant increase of total and positive selected thymocyte numbers, particularly in the number of CD3TCR(hi)CD69(+) DP thymocytes. Taken together, our results show that Erdr1 enhances the strength of TCR signaling and cellularity of thymocytes by amplifying Ca2+ influx in thymocytes receiving TCR signals.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
원격대학원 > 향장미용학과 > 1. Journal Articles

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Kim, Kyung Eun
원격대학원 (향장미용학과)
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